Insig: a significant integrator of nutrient and hormonal signals.
نویسنده
چکیده
Lipogenesis is regulated by sterols and by insulin through the regulated expression and activation of the sterol regulatory element-binding proteins (SREBPs). A new study shows one way in which sterol and insulin regulation can be decoupled. In transgenic mice overexpressing a protein that regulates SREBP activation, lipogenesis is more sensitive to cholesterol and less sensitive to insulin.
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 113 8 شماره
صفحات -
تاریخ انتشار 2004